A pharmaceutical for curing urolithiasis and a manufacturing method thereof are disclosed. The manufacturing method comprises the steps of: (a) uniformly mixing an active ingredient capable of curing urolithiasis and a pharmaceutically acceptable excipient that are simultaneously added in an adequate mixing container to form a mixture (b) fabricating the mixture into a solid dosage form and (c) performing a heat treatment to the solid dosage form at the temperature of 50DEG C to 100DEG C to obtain the pharmaceutical for curing urolithiasis. Accordingly, with the solid dosage form to be processed by the heat treatment, a pharmaceutical provided with an adjustable release rate for curing urolithiasis can be obtained, and problems such as diarrhea, gastrointestinal ulcer or even death resulted from the rapid release of active ingredient for curing urolithiasis in conventional skills can be solved.本發明揭示一種用於治療尿路結石疾病之醫藥品及其製造方法,其中製造方法包括(a)將可治療尿路結石之活性成份以及藥學上可接受的賦型劑同時加入至一適當的混合容器內均勻混合,以形成一混合物;(b)將該混合物進行固體劑型的製作;(c)將該固體劑型於50℃至100℃溫度下進行熱處理,以獲得所述之治療尿路結石疾病之醫藥品。本發明藉由熱處理固體劑型,以獲得可調控釋放速率之治療尿路結石疾病之醫藥品,並解決先前技術因該治療尿路結石之活性成份快速釋放所以引的腹瀉、腸胃道潰瘍甚至死亡等問題。
