The present invention is directed to a door handle sanitizing cassette that is installed within an internal cavity formed within a door. Prior to the installation, the cassette is fitted with all required door hardware and the equipment necessary to spray the door handles with a sanitizing liquid each time the door is opened or at preset intervals. The invention is designed to provide an inexpensive and easily installed system in public buildings to substantially reduce the spread of infectious disease by eliminating contaminated surfaces on the door handles.
