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APPLICATION OF 5-AMINOLEVULINIC ACID AND ITS DERIVATIVES IN A SOLID FORM FOR PHOTODYNAMIC TREATMENT AND DIAGNOSTICS
专利权人:
ФотоКьюэр АСА (NO)
发明人:
КЛАВЕНЕСС Йо (NO),СТЕНСРУД Грю (NO),ГОДАЛЬ Аслак (NO),БРАЭНДЕН Йон Эрик (NO),КЛЕМ Бьорн (NO)
申请号:
RU2014112548/15
公开号:
RU2014112548A
申请日:
2014.04.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A solid pharmaceutical product containing a photosensitizer, which is a 5-aminolevulinic acid ester (5-ALA) of general formula I or a pharmaceutically acceptable salt thereof: wherein R is a substituted or unsubstituted unbranched, branched or cyclic alkyl group, and each R is independently a hydrogen atom ; and at least one pharmaceutically acceptable carrier or excipient, which is a solid fat or a mixture of solid fat and additives; wherein said pharmaceutical odukt presented in the form of suppozitoriya.2. A solid pharmaceutical product according to claim 1, adapted for administration into the uterus, vagina or cervix. 3. The solid pharmaceutical product of claim 2, adapted for administration to the vagina. 4. A solid pharmaceutical product according to claim 1, having a melting point of from 30 to 37 ° C. The solid pharmaceutical product according to claim 1, wherein said solid fat or a mixture of solid fat and additives has a melting point of 31 to 33 ° C. The solid pharmaceutical product according to claim 1, comprising solid fat. The solid pharmaceutical product according to claim 6, wherein said solid fat is Witepsol H32.8. A solid pharmaceutical product according to claim 1, comprising a mixture of solid fat and additives. The solid pharmaceutical product of claim 8, wherein said mixture of solid fat and additives is Witepsol S58.10. The solid pharmaceutical product according to claim 1, wherein, in the formula I, R 1 represents an unsubstituted alkyl group, preferably C 1-6 alkyl, or an alkyl group, preferably C 1-6 alkyl, substituted with an aryl group. The solid pharmaceutical product according to claim 10, wherein, in formula I, Rpred1. Твердый фармацевтический продукт, содержащий фотосенсибилизатор, который представляет собой эфир 5-аминолевулиновой кислоты (5-ALA) общей формулы I или его фармацевтически приемлемую соль:гдеRпредставляет собой замещенную или незамещенную неразветвленную, разветвленную или циклическую алкильную группу, икаждый Rнезави
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