FUNDACIO PRIVADA INSTITUCIO CATALANA DE RECERCA IESTUDIS AVANÇANTS;FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON
发明人:
ARRIBAS LÓPEZ, JOAQUÍN,PEDERSEN, KIM,ANGELLINI, PIER-DAVIDE,PARRA, PALAU JOSEP LLUIS,BASELGA, TORRES JOSÉ
申请号：
HRP20141257
公开号：
HRP20141257T1
申请日:
2014.12.23
申请国别(地区):
HR
年份:
2015
代理人:
摘要：
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-61 1, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6) . The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
