LITTLER BENJAMIN JOSEPH,LOOKER ADAM R.,CHOUDHURY ANUSUYA,HARRISON CRISTIAN L.,VELURI RAVIKANTH,RYAN MICHAEL P.,JIANG LICONG,LUSS-LUSIS EDUARD
申请号：
NZ62444012
公开号：
NZ624440A
申请日:
2012.11.08
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed are indole compounds of formula (II), wherein the substituents are as defined in the specification. The disclosed compounds are useful as modulators of ATP-Binding Cassette (&rdquo；ABC&rdquo；) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (&rdquo；CFTR&rdquo；). An example of a compound of formula (II) is: (R)-2-(5-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-1-(2,3-dihydroxypropyl)-6-fluoro-1H-indol-2-yl)-2- methylpropanoic acid
