The depot compositions of injectable are suitable for intramuscular formation solid implant in situ in the body, it, which contains, carries out in paliperidone medicinal or its officinal salt and/or any combination thereof, it is biocompatible to have lactic acid and glycolic acid monomers proportion for 50:50 and in DMSO solvents based on lactic acid and ethanol copolymer, wherein there is the composition release drug direct effect to start, and continue at least 8 weeks, and wherein the composition has a pharmacokinetic profile, suitable for said preparation every 8 weeks or even longer time to be administered in vivo.
