VECTEUR EXPRIMANT UN VARIANT DU FACTEUR VIII AYANT UNE CAPACITÉ D'EXPRESSION DE LA PROTÉINE ACCRUE

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专利权人:

G&P Bioscience Co., Ltd.;Reyon Pharmaceutical Co., Ltd

发明人:

申请号：

EP18886810.3

公开号：

EP3722426A1

申请日:

2018.12.05

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present disclosure relates to an expression vector that carries a polynucleotide coding for a coagulation factor VIII mutant and has increased protein expression and a pharmaceutical composition containing the expression vector for preventing or treating hemorrhagic disease or hemorrhage.The factor VIII mutant of the present disclosure is derived by deleting a part of the B-domain (residues 784-1667) and a part of the a3 region (residues 1668-1671) in factor VIII and, as a result, an expression vector carrying a polynucleotide coding for the factor VIII mutant has remarkably increased protein expression.

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中国工程科技知识中心

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