The present invention relates to Indoleamine 2,3-dioxygenase inhibitor represented by formula (I), its preparation method and the use thereof. The inhibitor of Indoleamine 2,3-dioxygenase (IDO for short) is the derivative of (Z)-N-hydroxy-N-phenylformamidine. It has a high inhibitory activity against IDO and can effectively inhibit the activity of IDO, and also can be used for inhibiting immunosuppression of patients. It can be widely used to treat or prevent cancer, tumor, viral infection, depression, neurodegenerative diseases, trauma, age-related cataracts, organ transplant rejection or autoimmune diseases, and it is expected to be developed into a new generation of immunosuppressive agents.本發明涉及一種具有式(I)結構的吲哚胺2,3-雙加氧酶抑制劑及其製備方法與應用。該吲哚胺2,3-雙加氧酶(IDO)抑制劑是(Z)-N-羥基-N-苯基甲脒衍生物,對IDO具有很高的抑制活性,能夠有效抑制IDO的活性,也可用於抑制患者的免疫抑制。可廣泛應用於治療或預防癌症或腫瘤、病毒感染、抑鬱症、神經變性病症、創傷、年齡相關的白內障、器官移植排斥或自身免疫疾病,有望開發成新一代免疫抑制劑。
