Disclosed herein are [1,3,4]thiadazol-2-yl sulfamic acid derivatives of the given formula, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds. Said compounds are useful as human protein tyrosine phosphatase beta (HPTP-B) inhibitors and as such are useful in regulating angiogenesis, treating skeletal muscle and myocardial ischemia, stroke, coronary artery disease, peripheral vascular disease, coronary artery disease, promoting the growth of skin graft replacements and for vascularizing ischemic tissue.
