The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.本發明大體上係關於LRRK2抑制劑或其醫藥學上可接受之鹽、氘化類似物、前藥、互變異構體、立體異構體或立體異構體混合物,以及其製造及使用方法。