БАЖИНА Наталия (US),ДОНАТО Джордж Джозеф (US),ФАБИАН Стивен Р. (US),ЛОКНОТ Джон (US),МЕГАТИ Сринивасулу (US),МЕЛУЧЧИ Чарльз (US),ОФСЛЭЙГЕР Кристиан (US),ПАТЕЛ Никета (US),РЭЙДБО Гэйлен (US),ШАХ Саед М
申请号：
RU2013157119/15
公开号：
RU2013157119A
申请日:
2013.12.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound of formula I: where: R and R are each independently a Saliphatic group and X is a corresponding anion. 2. A compound according to claim 1, wherein X is an anion of the corresponding Bronsted acid. 3. A compound according to claim 2, wherein the Bronsted acid is hydrohalide, carboxylic acid, sulfonic acid, sulfuric acid, or phosphoric acid. The compound of claim 2, wherein X is chloride, bromide, iodide, fluoride, sulfate, bisulfate, tartrate, nitrate, citrate, bitartrate, carbonate, phosphate, malate, maleate, fumarate sulfonate, methyl sulfonate, formate, carboxylate, sulfate, methyl sulfate trifluoroacetate or succinate. 5. A compound according to claim 4, wherein X is bromide. 6. A compound according to claim 1, in which R represents a Saliphatic group and R represents lower alkyl. A compound according to claim 6, wherein R1 represents a (cycloalkyl) alkyl group or an alkenyl group. A compound according to claim 7, in which R 1 is cyclopropylmethyl or allyl and R 1 is methyl. A compound according to claim 1, wherein said compound is of formula II or II ′: wherein each X is a corresponding anion. The compound of claim 9, wherein said compound is compound II-1 or II-2: 11. The crystalline form of compound II-1: 12. A method comprising the steps of: (a) obtaining a sample of (R) -N-methylnaltrexone bromide； (b) analyzing a sample of (R) -N-methylnaltrexone bromide and (c) determining the amount of compound II-1 in sample (R) -N methylnaltrexone bromide. 13. The method of claim 12, wherein step (c) further comprises the step of determining the amount of compound IV-1 in the sample1. Соединение формулы I:где:Rи Rпредставляют собой, каждый, независимо Cалифатическую группу иXпредставляет собой соответствующий анион.2. Соединение по п. 1, где Xпредставляет собой анион соответствующей кислоты Бренстеда.3. Соединение по п. 2, в котором кислота Бренстеда представляет собой гидрогалогенид, карбоновую кислоту, сульфоновую кислоту, серную кислоту или фосфорную
