Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.本文提供包含類鐸(toll-like)受體促效劑之抗體共軛物及該等共軛物用於治療癌症之用途。在一些實施例中,該等共軛物包含抗HER2抗體。