IADONATO, SHAWN P.,怡艾多奈托 尚恩Ｐ,TARCHA, ERIC J.,塔恰 艾瑞克Ｊ,怡艾多奈托 尚恩P,塔恰 艾瑞克J
申请号：
TW104110742
公开号：
TW201542231A
申请日:
2012.06.05
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
Disclosed herein are pharmaceutical compositions having the sequence Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-GIy-Thr-Cys (SEQ ID NO:1). The disclosed compositions can include an acid or amide at the C-terminus of SEQ ID NO: 1 and the polypeptide can be attached to an organic or inorganic chemical entity that has an anionic charge. The polypeptide can be detectably labeled for diagnostic purposes. Methods of manufacturing and using the pharmaceutical compounds are also disclosed.本發明揭示一種具有序列Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Xaa-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys(SEQ ID NO：1)的醫藥組合物。所揭示之組合物在SEQ ID NO：1之C端可包括酸或醯胺，且該多肽可鍵連至帶負電荷離子的有機或無機化學實體。該多肽可標記可檢測之標記，以用於診斷之目的。本發明亦揭示製造及利用該等醫藥化合物之方法。
