Methods and systems for sterilizing a room are disclosed, including using a laser positioned within a housing to generate a pulsed laser beam and intercepting the pulsed laser beam with a scattering optical element to substantially isotropically scatter the radiation of the pulsed laser beam outside the housing to sterilize the room. The scattering optical element comprises a hollow fused silica bulb filled with solid fused silica spheres or a fiber optic bundle and in some embodiments the scattering optical element is rotated. The pulsed laser beam comprises a wavelength ranging between about 200 nm to about 320 nm and in some embodiments comprises nanosecond or picosecond light pulses. Other embodiments are described and claimed.
