A system and method for digital x-ray imaging. The method includes emitting a first and second collimated x-ray beam from an x-ray source disposed in a first and second position, respectively. The first and second collimated x-ray beam is directed onto an identified region of interest (ROI) wherein a first and second ROI image is captured, respectively, when the x-ray source is disposed in the first and second position, respectively. The first and second ROI images are processed to extract features from each of the first and second ROI images. The extracted features are analyzed, and an indicator of a disease is generated responsive to the extracted features. The indicator can be stored, displayed, or transmitted. The first and second x-ray sources can be the same or different x-ray sources.
