NIELSEN SIMON FELDBÆK,LARSEN JENS CHRISTIAN HØJLAND
申请号：
NZ62584912
公开号：
NZ625849A
申请日:
2012.12.19
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are [1,2,4]triazolopyridine compounds of general formula (I), wherein R is a branched butyl group. Examples of the compounds include [( R)-1-Methylpropyl] 1-[8-methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate, free base, Tert-butyl 1-[8-methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate, free base and [(1S)-1-methylpropyl]1-[8-methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate, free base. The compounds are phosphodiesterase (PDE) 4 inhibitors. The compounds may be useful in the treatment of proliferative and inflammatory skin disorders, dermatitis, atopic dermatitis, seborrheic dermatitis, contact dermatitis, psoriasis, cancer, epidermal inflammation, alopecia, skin atrophy, steroid induced skin atrophy, skin ageing, photo skin ageing, acne, urticaria, pruritis, and eczema.
