The present invention relates to a closed structure of a tablet press punch and a tablet compression forming device using the same. The closed structure of a tablet press punch comprises: a punch holder provided with a plurality of guide holes formed at regular intervals along a circumferential direction; a punch vertically moving in an axial direction through the guide hole of the punch holder; and a sleeve magnetically coupled to the punch holder to seal the outside of the punch protruding from the guide hole of the punch holder. According to an embodiment of the present invention, the outside of the guide hole and punch is sealed with the sleeve to prevent a lubricating oil and other foreign substances from being added to the powder raw material of the tablet, thereby preventing contamination of the powder raw material, wherein the lubricating oil is supplied for smooth operation of the tablet press punch for compressing a powder raw material fed into a tablet forming hole of a main disk and forming a tablet, and the other foreign substances flows through the guide hole through which the punch passes. Further, the sleeve has a bellows body whose length is variable depending on the operation of the punch such that the operation of the punch is not affected. One end or both ends of the sleeve are magnetically coupled to one end of the punch holder or the punch, thereby enhancing the ease of attachment and detachment of the sleeve and the binding force. In addition, the one end or both ends of the sleeve are coupled to the one end of the punch holder or the punch in a one-touch manner by a detachment member, thereby improving the ease of attachment and detachment of the sleeve.본 발명은 원주방향을 따라 일정간격으로 복수개의 가이드공이 형성된 펀치홀더; 상기 펀치홀더의 가이드공을 관통하여 축 방향으로 수직 운동하는 펀치; 및 상기 펀치홀더에 자성 결합되어 상기 펀치홀더의 가이드공으로부터 돌출된 상기 펀치의 외측을 밀폐하는 슬리브;를 포함하는 타정기 펀치의 밀폐구조체 및 이를 이용한 정제 압축 성형 장치를 제공한다.본 발명의 실시 예에 따르면, 메인디스크의 정제성형공에 투입되는 분말원료를 압축하여 정제를 성형하는 타정기 펀치의 원활한 작동을 위해 투입되는 윤활유와 펀치가 통과되는 가이드공을 통