GHAYUR, TARIQ,LIU, JUNJIAN,JAKWAY, JAMES J.,TALANIAN, ROBERT V.,BENATUIL, LORENZO
申请号：
PE2012002480
公开号：
PE20130614A1
申请日:
2011.06.23
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
It refers to the polymerized protein, including the first and second polymerized chains, including VD1 - (x1) n-vd2-c - (x2) n, wherein: VD1 is the first variable domain； VD2 is the second variable domain； C is a constant domain； X1 is a connector without ch1 condition； X2 is a region FC； FC is A. variant of FC sequence in immunoglobulin region；N is 0-1, in which the VD1 domain name forms the first functional white alliance website in the first and second polyurethane chains, while the VD2 domain name forms the second functional white alliance website in the first and second polyurethane chains, and the alliance proteome has the ability to connect TNF and tweak together, where: (I) domain name The variables of TNF functional white alliance website include three CDRs of SEQ ID 28 and SEQ ID 29； and (2) the variable fields of tweek functional white alliance website include three CDRs of SEQ ID 30,SEQ ID No.31 or SEQ ID No.32 and SEQ ID No.33. There are also associated proteins, including the first two polypeptide chains and the second polypeptide chain. Except for a pharmaceutical composer This combined protein is useful in the treatment of acute, chronic and cancer inflammation.SE REFIERE A UNA PROTEINA DE UNION QUE COMPRENDE UNA PRIMERA Y UNA SEGUNDA CADENA DE POLIPEPTIDICA EN DONDE LA CADENA POLIPEPTIDICA COMPRENDE VD1-(X1)n-VD2-C-(X2)n EN DONDE: VD1 ES UN PRIMER DOMINIO VARIABLE； VD2 ES UN SEGUNDO DOMINIO VARIABLE； C ES UN DOMINIO CONSTANTE； X1 ES UN CONECTOR CON LA CONDICION QUE NO SEA CH1；X2 ES UNA REGION Fc； Fc ES UNA VARIANTE DE LA SECUENCIA DE LA REGION Fc DE UNA INMUNOGLOBULINA ； n ES 0 - 1； EN DONDE LOS DOMINIOS VD1 EN DICHA PRIMERA Y SEGUNDA CADENA DE POLIPEPTIDOS FORMAN UN PRIMER SITIO DE UNION BLANCO FUNCIONAL Y LOS DOMINIOS VD2 EN DICHA PRIMERA Y SEGUNDA CADENA DE POLIPEPTIDOS FORMAN UN SEGUNDO SITIO DE UNION BLANCO FUNCIONAL, Y DONDE LA PROTEINA DE UNION TIENE LA CAPACIDAD DE UNIR TNF Y TWEAK, DONDE: (i) LOS DOMINIOS VARIABLES QUE FORMAN UN SITIO DE UN
