An applicator with a liquid medicine where even when an accidental external pressure is applied during transport or storage, there is no possibility that a liquid medicine storage member is opened and a liquid medicine is impregnated into an applying member so that the liquid medicine can be reliably held but, at the same time, the liquid medicine can be easily impregnated into the applying member when necessary. The applicator with a liquid medicine includes a storage member for storing an applying member, the storage member includes: a bottom film in which the applying member is stored and a top film which closes the bottom film thus storing the applying member and a liquid medicine storage member, in which the liquid medicine is sealed, in the storage member, and the bottom film has an air chamber capable of storing at least the applying portion and a predetermined amount of air.