Provides a compound for use as a protein kinase B inhibitor, a salt thereof or a compound of formula (I), their solvates, or tautomers thereof N- its oxides, the invention where T is the It is CR 5 or N, J 1 -J 2 is N = C (R 6), (R 7) C = N, (R 8) N-C (O), (R 8) 2 C-C (O or N = N,,) (R 7) C = C is (R 6), E is a heterocyclic group or a monocyclic carbocyclic 5 or 6 ring members, heterocyclic group O, N , and contains three heteroatoms following elements selected from S, Q 1 is a 1-3 hydrocarbon linker group C a saturated bond or one of the carbon atoms in the linker group by a nitrogen atom or an oxygen atom, optionally adjacent pairs of carbon atoms are replaced by NR q CO or CONR q, or replaced, R q is optionally bonded to a carbon atom of Q 1 or R 1 Metropolitan R q, or is hydrogen or methyl wherein and a C 1-4 alkylene chain that forms a cyclic moiety, wherein the carbon atoms of the linker group Q 1 has optionally one or more substituents are selected from fluorine and hydroxy, Q 2 is a bond or It is a saturated hydrocarbon linker group containing 1 to 3 carbon atoms, one of the carbon atoms in the linker group is replaced by oxygen or nitrogen atom, optionally wherein the carbon atoms of the linker group selected from fluorine and hydroxy and a optionally substituted with one or more members, provided it is not located on the carbon atom in α-position to the group G, but is aryl or heteroaryl is E in the case of the hydroxy group is present If, Q 2 is other than a bond, G is SH or 3, OH, hydrogen, NR 2 R, with the proviso that when E is aryl or heteroaryl, when Q 2 is a bond, is hydrogen G , R 1 is an aryl or heteroaryl group or a hydrogen, provided that R 1 is hydrogen and G is NR 2 R 3, Q 2 is a bond, R 2, R 3, R 4, R 6, and R 8 have the same meanings as those defined in the claims.本発明はプロテインキナーゼB阻害剤として使用される化合物を提供し、式(I)の化合物あるいはその塩、その溶媒和物、その互変異性体、またはそのN‐オキシドである、ここでTはNまたはCR5であり、J1‐J2はN=C(R6)、(R7)C=N、(R8)N‐C(O)、(R8)2C‐C(O)、N=N、または(R7)C=C(R6)であり、Eは5または6環員の単環炭素環式また
