Method for activating receptor by cofactor and utilization of ligand activity

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专利权人:

独立行政法人産業技術総合研究所

发明人:

鈴木 理,今村 亨,上原 ゆり子,本村 香織,隠岐 潤子,岡 修一,浅田 眞弘,倉持 明子,木村 美穂

申请号：

JP2008099837

公开号：

JP5187837B2

申请日:

2008.04.07

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/