Adaptive Biotechnologies Corp.;Fred Hutchinson Cancer Research Center
发明人:
ROBINS, Harlan S.,EMERSON, Ryan O.,DEWITT, William Sumner, III
申请号：
EP20150864123
公开号：
EP3224384(A4)
申请日:
2015.11.24
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of T cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. Unique responding effector cell clones and abundance thereof can be determined. Additionally, methods for determining the contribution of responding effector cells to the immunological memory compartment are provided.
