Zewge, Daniel,Copeland, Gregory T.,Li, Zhen,Armstrong III, Joseph D.
申请号：
AU2013361605
公开号：
AU2013361605A1
申请日:
2013.12.18
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
This invention relates to the post-synthetic chemical modifications of RNA at the 2' -position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions. RNA interference (RNAi) is an evolutionarily conserved cellular mechanism of post-transcriptional gene silencing found in fungi, plants and animals that uses small RNA molecules to inhibit gene expression in a sequence-specific manner. The RNAi machinery can be harnessed to destruct any mRNA of a known sequence.
