National University Corporation Tokyo Medical and Dental University;National University Corporation Kumamoto University
发明人:
Hideki Hayashi
申请号：
US14346002
公开号：
US20140228299A1
申请日:
2012.09.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides an agent for neurological disease, the agent comprising lipoprotein containing apolipoprotein E as the active substance thereof, in which a neuroprotective system via activation of neuroprotective molecules and/or the inactivation of neurodegeneration-inducing molecules, mediated by lipoprotein receptors, may work as a mechanism, and a prophylactic and therapeutic method for neurological diseases. The lipoproteins containing apolipoprotein E and/or neuroprotective system through, as the action mechanism, the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors have prophylactic and therapeutic effects of, including, inhibiting nerve cell apoptosis, on neurological disease such as various neurodegenerative diseases accompanied by nerve cell apoptosis as the essential condition. The invention provides the agent comprising apolipoprotein E-containing lipoproteins and/or having an action mechanism through the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors.
