Donna Marie Stone;Ping Wei;Kang Li;Qinghai Peng;John Andrew Lippincott;Zdenek Hostomsky
发明人:
Kang Li,Ping Wei,Qinghai Peng,John Andrew Lippincott,Donna Marie Stone,Zdenek Hostomsky
申请号：
US13378791
公开号：
US09090690B2
申请日:
2010.06.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
