Stefan H. Bossmann,Deryl L. Troyer,Matthew T. Basel,Tej B. Shrestha,Hongwang Wang
申请号：
US13800456
公开号：
US09216154B2
申请日:
2013.03.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.
