Peters, Jan Georg,Militzer, Hans-Christian,Muller, Hartwig
申请号：
AU2012238891
公开号：
AU2012238891B2
申请日:
2012.03.29
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates : - to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo- [1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II) : or a tautomer, solvate or hydrate thereof； - to methods of preparing said dihydrochloride salt； - to said dihydrochloride salt for the treatment and/or prophylaxis of a disease； - to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer； - to a pharmaceutical composition comprising said dihydrochloride salt； and - to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
