Paraskevi Sakellariou,Andrea O'Neill,Joseph A. Roche,Robert J. Bloch,Amber L. Mueller
申请号：
US16813263
公开号：
US20200282210A1
申请日:
2020.03.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates to methods of treating a subject having a muscle disorder by identifying a subject having a muscle disorder in need of treatment； injecting human myogenic precursor cells in an amount capable of forming mature muscle tissue into a portion of a limb of the subject； subjecting a nerve of the limb to therapeutic stimulation configured to enhance engraftment of the human myogenic precursor cells； and creating a graft of the human myogenic precursor cells to promote generation of mature muscle tissue, wherein the generation of mature muscle tissue improves muscle function. Preferably, the subject is a mammal, such as a human or a non-human mammal. In some embodiments, the non-human mammal is immunocompromised and the limb is irradiated. The engraftment can be promoted by a means other than therapeutic electrical stimulation (preferably intermittent neuromuscular electrical stimulation), for example by exercise.
