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Ciclofilinas Inhibitors for use in the Prevention and \/ or treatment of Viral Diseases or infections
专利权人:
Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人:
GUICHOU, Jean-François,COLLIANDRE, Lionel,AHMED-BELKACEM, Hakim,PAWLOTSKY, Jean-Michel
申请号:
ES10798084
公开号:
ES2670394T3
申请日:
2010.12.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of formula (i): * * * * in the formula: - n is 0, 1 or 2 - a is CH or C and together with R1, R2 and Co, a group heterociclilo which comprises 5 to 20 Atoms.X is possibly replaced - CO - or CS, R1 is selected from the group consisting of H, alkyl groups, and groups aralquilo, and such aralquilo or possibly substituted alkyl groups,- R2 is a group of nr3r4 or OR5 formula, in which: - R3 and R4 are each independently: H, alkyl groups, aralquilo ora, Groups and aryl groups,Choosing ra group consisting of H, alkyl groups, aryl groups, and groups in which aralquilo R3 and R4 can form, along with the nitrogen Atom That Lead,A group heterociclilo which comprises 5 to 20 ATOMS, possibly replaced - R5 is selected from aryl, alkyl groups, groups, and groups aralquilo in R5, which can form.Along with the Oxygen Atom which carries a group of 5 to 20 heterociclilo ATOMS, possibly replaced, R6 is H or an alkyl group.Or you can join a group heterociclilo R2 20 to 30 carbon ATOMS, or may form along with a group heterociclilo R1 10 to 30 Atoms.R7 is selected from the group consisting of: - aryl heteroaryl groups, groups, nhph, heterociclilo groups and alkyl groups in the R7 is aryl or heteroaryl when, heterociclilo,Is substituted with at least one NH2 Group, or its pharmaceutically acceptable salts, hydrates or hydrated salts or their polymorphic crystal structures, racematos, Diastereomers or enantiomersFor use in the Prevention and \/ or treatment of Viral Diseases or infections.The said Compound has the formula (iii): * * * * in the formula that ra and R4 are as defined above,This Compound has the formula or formula (iv): * * * * In The R3 and R4 are as defined above,The Compound has the formula (V): * * * * formula, in which R1 is as defined above,And R3 and R4 form along with the nitrogen Atom that lead a group which has the formula: * * * * formula where n is 0, 1 or 2, and R is H or optionally substituted aryl,This Compound has the formula or formula (VI): * * * * In
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