BOEHRINGER INGELHEIM INTERNATIONAL GMBH;ZEALAND PHARMA A/S
发明人:
DIETER WOLFGANG HAMPRECHT,MARIA DERYABINA,JOLANTA SKARBALIENE,JESPER MOSLOFF MATHIESEN,HENRIK MUNCH,JESPER SLOTH VILLADSEN,LISE GIEHM,OLIVER DEMMER,RASMUS JUST
申请号：
ARP160100708
公开号：
AR103954A1
申请日:
2016.03.17
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
The present disclosure relates to amylin analogs and their use in the treatment and / or prevention of a multiplicity of conditions, conditions or disorders, including obesity, excessive food consumption and related metabolic diseases such as diabetes. The analogues have good physical and chemical stability and long action, and are well suited for use in the form of a liquid formulation. Claim 1: An amylin analog which is a compound having the formula: R¹-Z-R² where R¹ is hydrogen, C₁₋₄ acyl,benzoyl or C₁₋₄-alkyl or an M-group that prolongs the half-life, wherein M is optionally linked to Z by means of a bond moiety L； R² is OH or NHR³,2. R3 is hydrogen or c833218331-83323；9y-x83r-h1-x8383r (x83r)； contents (Continued)where X³ is selected from the group consisting of Asn, Gly, Pro and Gln； X¹⁰ is selected from the group consisting of Gln, Asp and Glu； X¹⁴ is selected from the group consisting of Asp, His, Asn and Aad； X¹⁷ is selected from the group consisting of His, Asn, Gln, Glu, Thr, Val, Lys and Aad； X¹⁹-X²⁰ is selected from the group consisting of Ser-Ser, Val-Val, Ser-Val and Val-Ser or is not present； X³¹ is selected from the group consisting of Asp, Glu and Asn； X³⁵ is selected from the group consisting of Asp, Glu, Asn, Ser, Phe, Orn, Aad, Gly and Thr； and X³⁷ is selected from the group consisting of Pro, Apr and Hyp；And the compound has at least one selected remaining part: X3 is Gln； x1 83088 is HS, ASN or aad； x1 8311 is ASN, Gln, Glu, thr or aad； x1 8313-x 83044 is Val Ser or ser Val； x383309 is ser, Phe, ORN, AAD, Gly or thr； or salt or solution acceptable for the same agent.La presente divulgación se refiere a análogos de amilina y a su uso en el tratamiento y/o la prevención de una multiplicidad de afecciones, estados o trastornos, incluyendo obesidad, consumo excesivo de alimentos y enfermedades metabólicas relacionadas tal como diabetes. Los análogos presentan una buena estabilidad física y química y una acción prolongada y se adecuan bien para su
