The present invention provides a handy remote physiological signal detection system, comprising a sensing unit, a stimulation unit and a control unit. The sensing unit includes a detecting electrode, a first surface detection electrode, a second surface detection electrode and a sensing module. The sensing modules is used to detect the signals between the detection electrode and the first surface detection electrode to get an epicardial detection signal, and is also used to detect the signals between the second surface detection electrode and the first detection electrode to get a surface-ECG signal. The stimulus unit includes a stimulating electrode and a stimulus module used to provide a stimulus signal to the stimulating electrode. The control unit includes a user interface and a processing module used to convert the epicardial detection signal and the surface-ECG signal to digital signals and display the digital signals in the user interface. All systems were controlled through the remote system and are small and handy.