使用ＩＬ－１７拮抗劑治療關節黏連性脊椎炎之方法农业专利-农业专业知识服务系统

发明人:: BEK, STEPHAN,贝克　史丹芬,貝克　史丹芬,BRACHAT, ARNDT,巴克　安德特,HUEBER, WOLFGANG,汉伯　渥夫甘,漢伯　渥夫甘,LI, YALI,李亚莉,李亞莉,WANG, YING,汪盈,YELENSKY, ROMAN,伊兰斯基　罗曼,伊蘭斯基　羅曼,贝克史丹芬,貝克史丹芬,巴克安德特,汉伯渥夫甘,漢伯渥夫甘,伊兰斯基罗曼,伊蘭斯基羅曼

摘要：: The disclosure is directed to novel personalized therapies and methods for treating ankylosing spondylitis (AS). Specifically, this disclosure relates to methods of treating a patient having AS by selectively administering an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, to the AS patient on the basis of that patient being predisposed to have a favorable response to treatment with the IL-17 antagonist. Also disclosed herein are diagnostic methods and transmittable forms of information useful in predicting the likelihood that a patient having AS will respond to treatment with an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab.本發明係關於用於治療關節黏連性脊椎炎(AS)之新穎個人化療法及方法。特定言之，本發明係關於治療患有AS之患者的方法，其藉由基於該患者傾向於對接受IL-17拮抗劑治療具有有利反應而向該AS患者選擇性投與該IL-17拮抗劑，例如IL-17抗體，諸如塞庫金單抗(secukinumab)。本文中亦揭示適用於預測患有AS之患者將對接受IL-17拮抗劑(例如IL-17抗體，諸如塞庫金單抗)治療有反應之可能性的診斷方法及可傳送資訊形式。