SHOICHET, MOLLY S.,YUAN, YUMIN,SHI, MENG,WOSNICK, JORDAN
申请号：
CA2614049
公开号：
CA2614049C
申请日:
2006.07.06
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The application provides a method for the covalent immobilization ofbiomoleculeson polymer micro- or nano-particles. A modified micro/nanoparticle system isprovided,which uses a functionalized polymer formed into micro or nanoparticles to bindamolecule to the particles, e.g. using Diels-Alder cycloaddition or Huisgen 1,3-dipolarcycloaddition . The biomolecules and/or other therapeutic agents may beencapsulatedwithin the polymer particles for intravenous therapeutic delivery. Theapplication alsoprovides a novel synthetic biodegradable polymer, a furan/alkyne-functionalizedpoly(trimethylene carbonate) (PTMC)-based polymer, whose composition can bedesigned to meet defined physical and chemical property requirements.
