Disclosed herein are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery. The compositions comprise an NK1 receptor antagonist such as netupitant, a 5HT3 antagonist such as palonosetron, and/or dexamethasone. Additionally disclosed are dosage forms comprising tablets and/or soft-gel capsules containing the active ingredients further contained in an outershell.