ROB N. DE JONG,FRANK BEURSKENS,PAUL PARREN,ARAN FRANK LABRIJN,JANINE SCHUURMAN,ARJEN VLUG,SANDRA VERPLOEGEN
申请号：
PT13735254
公开号：
PT2869845T
申请日:
2013.07.05
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
To provide dimeric proteins having at least three mutations as compared to a parent dimeric protein.SOLUTION: Disclosed herein is a dimeric protein comprising a first polypeptide and a second polypeptide, where each polypeptide comprises at least C2 and C3 regions of a human immunoglobulin G heavy chain, in the first and second polypeptides, amino acids at positions corresponding to E345, E430 and S440 are R, G and Y, respectively； or alternatively K, G and Y, respectively； or alternatively R, S and Y, respectively； or alternatively R, G and W, respectively, where these amino acids are numbered according to EU numbering as set forth in Kabat.SELECTED DRAWING: None
