Starch urea borate based gastroretentive formulations for site specific (gastric region), controlled release and enhanced bioavailability of active pharmaceutical ingredients
The present invention relates to the field of pharmaceutical technology and describes preparation of starch urea borate and novel gastroretentive effervescent floating drug delivery systems (GEFDDS) employing starch urea borate for attaining site specific controlled release and enhanced bioavailability of active pharmaceutical ingredients (API"s). The novel starch urea borate matrix composition is suitable for producing GEFDDS of a large number of API"s. In the new GEFDDS an active ingredient is present essentially, uniformly dispersed in a matrix composed of starch urea borate with or without other additives such as gas generating agents, binding agents and floating enhancers. The matrix compositions are in the form of compressed tablets (prepared by melt granulation technique) as a platform technology for obtaining site specific (gastric region) and controlled release of API"s belonging to different chemical and pharmacological categories and which require gastroretentive formulation for enhanced bioavailability. GEFDDS employing starch urea borate are suitable for once a day gastroretentive drug delivery systems of several API"s.
