Brett Chevalier,Alexander Marson,Richard A. Young,Ruth Foreman,Rudolf Jaenisch
申请号：
US15429114
公开号：
US20170218341A1
申请日:
2017.02.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
