TARGETING TRASTUZUMAB RESISTANT HER2+BREAST CANCER WITH A HER3 TARGETING NANOPARTICLE

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专利权人:

发明人:

MEDINA KAUWE LALI K,SIMS JESSICA,TAGUAIM MICHAEL,HANSON CHRIS,CUI XIAOJIANG

申请号：

IN201627036600

公开号：

IN201627036600A

申请日:

2016.10.25

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

Disclosed herein are methods of treating cancer in a patient the method comprising identifying a patient who is resistant to treatment with an anti HER2 therapy and administering to the patient a drug delivery molecule comprising a polypeptide molecule adapted to target and/or penetrate a type of cell a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions and a chemical agent non covalently linked to the nucleic acid sequence. Also disclosed are methods of inducing apoptosis in an anti HER2 therapy resistant HER2+ breast cancer cell the method comprising contacting the anti HER2 therapy resistant HER2+ breast cancer cell with the drug delivery molecule. Further disclosed herein are methods of treating cancer in a patient the method comprising identifying a patient who is resistant to anti HER2 therapy and administering to the patient a therapeutically effective amount of a drug delivery molecule comprising a polypeptide molecule adapted to target and/or penetrate a type of cell and a sulfonated corrole molecule bound to the polypeptide sequence. Finally disclosed herein are methods of inducing apoptosis in an anti HER2 therapy resistant HER2+ breast cancer cell the method comprising contacting the anti HER2 therapy resistant HER2+ breast cancer cell with a drug delivery molecule comprising a polypeptide molecule adapted to target and/or penetrate a type of cell and a sulfonated corrole molecule bound to the polypeptide sequence

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中国工程科技知识中心

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http://www.ckcest.cn/home/