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MOLECULES DE LIAISON A L'ANTIGENE BISPECIFIQUES SE LIANT AU RECEPTEUR DE LA LEPTINE ET/OU A GP130, ET LEURS PROCEDES D'UTILISATION
专利权人:
INC.;REGENERON PHARMACEUTICALS
发明人:
GROMADA, JESPER,STEVIS, PANAYIOTIS,ALTAREJOS, JUDITH
申请号:
CA3084385
公开号:
CA3084385A1
申请日:
2018.12.17
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The present invention relates to antigen-binding molecules, including bispecific antigen-binding molecules that bind human GP130 and/or human leptin receptor (LEPR), and the use of such antigen-binding molecules for the treatment of conditions and disorders related to leptin deficiency or leptin resistance. The bispecific antigen-binding molecules of the present invention can be, e.g., bispecific antibodies comprising a first antigen-binding domain that specifically binds human GP130 and a second antigen-binding domain that specifically binds human LEPR. The bispecific antigen-binding molecules of the present invention are useful in therapeutic applications where induced leptin and/or LEPR-mediated signaling would be beneficial, e.g., in the treatment of obesity, lipodystrophies and other diseases and disorders associated with or caused by leptin deficiency or leptin resistance.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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