A barbed suture (90) including a body (92) with barbs (94) on the periphery, a pointed end (96), and an anchor (98) at one end to resist movement of the suture in the direction of the pointed end is provided. One or more limbs on the anchor may be provided, which may be arcuate, of varying lengths, and varying distribution about the periphery of the suture body. Other anchor designs are provided.