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РЕКОМБИНАНТНЫЕ САМОРЕПЛИЦИРУЮЩИЕСЯ ПОЛИЦИСТРОННЫЕ МОЛЕКУЛЫ РНК
专利权人:
НОВАРТИС АГ (CH)
发明人:
ЛИЛЬЯ Андерс (US),МЭЙСОН Питер (US)
申请号:
RU2014118727/10
公开号:
RU2014118727A
申请日:
2012.10.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Self-replicating RNA molecule comprising a polynucleotide which comprises: a) a first nucleotide sequence encoding a first protein or fragment thereof operably linked to a first subgenomic promoter (SGP) and b) a second nucleotide sequence encoding a second protein or fragment thereof operably linked to a second SGP c) a third nucleotide sequence encoding a third protein or fragment thereof operably linked to a third SGP and d) a fourth nucleotide sequence encoding a fourth protein or fragment thereof operably linked to a fourth SGP wherein, when the self-replicating RNA molecule is introduced into a suitable cell, are produced by first, second, third and fourth proteins or fragmenty.2. Self-replicating RNA molecule according to claim. 1, with the proviso that the first protein, second protein, a third protein and fourth protein are not one and the same protein or fragments of the same protein, the first protein is not a fragment of the second, third or fourth protein, the second protein is not a fragment of the first, third or fourth protein, a third protein is not a fragment of the first, second or fourth and fourth protein is a fragment of the protein is not the first, second or third belka.3. Self-replicating RNA molecule according to Claim. 1 or 2, further comprising a fifth nucleotide sequence encoding a fifth protein or fragment thereof operably linked to a fifth SGP.4. Self-replicating RNA molecule of claim. 1, characterized in that the first protein or fragment thereof, a second protein or fragment thereof, a third protein or fragment thereof and a fourth protein or fragment thereof and, if at1. Самореплицирующаяся молекула РНК, содержащая полинуклеотид, который содержит:a) первую нуклеотидную последовательность, кодирующую первый белок или его фрагмент, функционально связанный с первым субгеномным промотором (SGP) иb) вторую нуклеотидную последовательность, кодирующую второй белок или его фрагмент, функционально связанный со вторым SGPc) третью нуклеоти
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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