SCHWAB, WILFRIED,BIRKMANN, ALEXANDER,VÖGTLI, KURT,HAAG, DIETER,LENDER, ANDREAS,GRUNENBERG, ALFONS,KEIL, BIRGIT,REHSE, JOACHIM
申请号：
PL12762300
公开号：
PL2598501T3
申请日:
2012.09.26
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.
