AN IMPROVED PROCESS FOR PEGYLATION OF PROTEINS

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专利权人:

发明人:

申请号：

EP09839569.2

公开号：

EP2337794B1

申请日:

2009.05.04

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention relates to a process for improving pegylation reaction yield of r-metHuG-CSF comprising conjugating r-metHuG-CSF to a PEG aldehyde at a free amine moiety at the N terminal end on the G-CSF in presence of a reducing agent in a pegylation buffer solution comprising a polyol having the formula CnH2n+2On where n is from 3 to 6, or a carbohydrate, or a derivative thereof wherein the concentration of said polyol or carbohydrate or derivative thereof is in the range of 0.1% to 10% w/w.

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