High meat content extruded pet foods and methods of preparation thereof, preferably include initial treatment of a high moisture meat slurry to create a dewatered meat fraction and a liquid fraction. The liquid fraction is directed to an extruder, along with typical dry pet food ingredients, in order to create an extruded intermediate. This intermediate is then mixed with the dewatered meat fraction, and the mixture is then extruded and dried to create a final pet food. The methods may be carried out using separate processing systems each including a mixer, an extruder, and a drying assembly, in order to maximize production rates.