The use of a topical pharmaceutical composition as a medicament for the treatment of acne in the case of a human subject,said composition comprisinga cosmetically acceptable carrier, and a plurality of plasmonic nanoparticles in an amount of from 109 to 1018 Nanoparticles per milliliter of the composition,the silver or gold nanoparticles comprise plasmonic,the plasmonic nanoparticles in the case of a laser - wavelength in the range of infrared light absorbing； andthe nanoparticles plasmonic a hydrophilic or aliphatic coating include, wherein the coating does not substantially adsorbed on the skin of a mammal, and wherein the coating of polyethylene glycol, silicon dioxide, or polystyrene is selected, andwith acne is treated by means of a topical administration of the composition to a skin surface of the mammal - subject by providing a penetration by means of the redistribution of the plasmonic particles from the skin surface with a component of the dermal tissue, wherein the dermal tissue is a sebaceous gland, and by inducing a thermo modulation in a target tissue region by irradiating the skin surface with the aid of a light source, wherein the region of the target tissue is the sebaceous gland.İnsanlar gibi memelilere kozmetik, diyagnostik ve terapötik uygulamalar için faydalı olan nanopartiküller ve formülasyonlar sağlanmaktadır.
