ФРЭНК Дэниел В. (US),МАРТИН Ричард (US),ДАМАЖ Бассам Б. (US)
申请号：
RU2013141836/15
公开号：
RU2013141836A
申请日:
2012.04.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method for the treatment of Raynauds disease and Raynauds phenomenon in a subject, comprising the steps of: receiving a semi-solid composition containing a compound of prostaglandin E, and applying an effective amount of a semisolid composition onto the affected part tela.2. A method according to claim 1, characterized in that the semi-solid composition comprising: a. Compound of prostaglandin E, selected from the group consisting of prostaglandin E, C-Sefirov prostaglandin E and their pharmaceutically acceptable salts, a thickener, selected from polysaccharide gums, chemically-modified polysaccharide gum amplifier penetration through the skin, selected from ether N, N-di (CC) alkylamino substituted (CC) alkyl (CC) carboxylic acid and its pharmaceutically acceptable acid addition salts thereof islozhny ether (C-C) alkyl (CC) carboxylic kisloty.3. A method according to claim 2, characterized in that the ester of N, N-di (CC) alkylamino substituted (CC) alkyl (CC) of the carboxylic acid is selected from the group consisting of dodecyl-2- (N, N-dimethylamino) propionate. dodecyl-2- (N, N-dimethylamino) -acetate 1- (N, N-dimethylamino) -2-propyl dodecanoate 1- (N, N-dimethylamino) -2-propyl myristate 1- (N, N-dimethylamino) -2-propyl oleate and pharmaceutically acceptable acid addition soley.4. The method of claim. 1, characterized in that the semi-solid composition is supplied in a device for tempering individual doz.5. The method of claim. 1, characterized in that the semi-solid composition has a room temperature at the time of coating the surface of the affected part of the body to avoid triggering or acute vasospasm, which is characteristic for the disease, or Raynauds phenomenon Reyno.6. The method of claim. 1, characterized in that the semi-solid composition is stored at room temperature.7.1. Способ лечения болезни Рейно и феномена Рейно у субъекта, включающий стадии:получение полутвердой композиции, содержащей соединение простагландина E1, инанесение эффекти
