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Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
专利权人:
Novartis AG
发明人:
Deane, Jonathan,Diaz-De-Durana, Yaiza,Didonato, Michael,Filippi, Christophe,Spraggon, Glen
申请号:
AU2018274216
公开号:
AU2018274216A1
申请日:
2018.05.22
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
The present disclosure provides for IL2 engrafted into the CDR sequences of an antibody having preferred therapeutic profiles over molecules known and used in the clinic. In particular, the provided antibody cytokine engrafted protein compositions increase or maintain CD8+ T effector cells while reducing the activity of Treg cells. Additionally, provided compositions convey improved half-life, stability and produceability over recombinant human IL2 formulations such as Proleukin®.
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