Systems and methods for home monitoring and detection of febrile neutropenia in a patient are provided. The system includes a photoplethysmographic sensor for sensing photoplethysmographic signals of the patient, and one or more blood borne parameter sensors for sensing parameters in the patient's blood. A febrile neutropenia monitoring application receives information sensed by the photoplethysmography sensor and the one or more blood borne parameter sensors and determines, based on the received information, the presence or deterioration of febrile neutropenia. The method includes the steps of: sensing photoplethysmographic signals of the patient with a photoplethysmographic sensor worn by the patient； sensing blood borne parameters in the patient's blood with one or more blood borne parameter sensors； transmitting the sensed photoplethysmographic signals and blood borne parameters to a febrile neutropenia monitoring application； and determining, by the febrile neutropenia monitoring application, the presence or deterioration of febrile neutropenia based on the received information.
