FRASER, Douglas Dale,BARTHA, Robert,BROWN, Arthur,STEWART, Tanya Charyk,DALEY, Mark,DEKABAN, Greg A.,DOHERTY, Timothy,FISCHER, Lisa,HOLMES, Jeff,MENON, Ravi,RUPAR, Tony,SHOEMAKER, J. Kevin
申请号：
EP16767575
公开号：
EP3271720A4
申请日:
2016.03.18
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A method of diagnosing central nervous system injuries such as acquired brain injury (ABI) and/or acquired spinal cord injury (ASI), including mild TBI (concussion or blast wave), mild ASI (contusion, stretch or partial cord transection), non-TBI brain injury and/or non-TSI spinal cord injury in a subject (animal or human). The method includes (a) obtaining a biological test sample from the subject, identifying metabolites in the subject's sample using metabolomics thereby obtaining a subject's metabolite matrix and generating a subject's profile using the patient's metabolite matrix； and (b) using multivariate statistical analysis and machine learning to compare the subject's profile with predetermined set of profiles of CNS injuries and a predetermined set of profiles of controls to determine if the subject has a CNS injury.
