תכשירים של פולימיקסינים ותכשירי רוקחות המכילים אותם

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专利权人:

XELLIA PHARMACEUTICALS APS;VIDAR BJORNSTAD;CLAES MELANDER;MARTIN MANSSON;TORBEN KOCH;SOLVI GUNNES

发明人:

TORBEN KOCH,SOLVI GUNNES,VIDAR BJORNSTAD,CLAES MELANDER,MARTIN MANSSON

申请号：

IL23984015

公开号：

IL239840A

申请日:

2015.07.08

申请国别(地区):

IL

年份:

2017

代理人:

摘要：

Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I&prime；) R5 is &mdash；CH(CH3)2, &mdash；CH2CH(CH3)2, &mdash；CH(CH3)CH2CH3, or &mdash；CH2C6H5； R6 is &mdash；CH(CH3)2, &mdash；CH2CH(CH3)2, or &mdash；CH(CH3)CH2CH3； each of R2, R3, R4, R7 and R8 is either &mdash；(CH2)XCH2NH2 or &mdash；(CH2)xCH2N(CH2SO3M)2； wherein x is 0 or 1； wherein M is a monovalent cation； and wherein at least three of R2, R3, R4, R7 and R are &mdash；(CH2)xCH2N(CH2SO3M)2.

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